Phase II Study of Temsirolimus in Women With Recurrent or Metastatic Endometrial Cancer: A Trial of the NCIC Clinical Trials Group

PURPOSE: Phosphatase and tensin homolog (PTEN) is a tumor suppressor gene, and loss of function mutations are common and appear to be important in the pathogenesis of endometrial carcinomas. Loss of PTEN causes deregulated phosphatidylinositol-3 kinase/serine-threonine kinase/mammalian target of rap...

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Bibliografiske detaljer
Main Authors: Oza, Amit M., Elit, Laurie, Tsao, Ming-Sound, Kamel-Reid, Suzanne, Biagi, Jim, Provencher, Diane Michele, Gotlieb, Walter H., Hoskins, Paul J., Ghatage, Prafull, Tonkin, Katia S., Mackay, Helen J., Mazurka, John, Sederias, Joana, Ivy, Percy, Dancey, Janet E., Eisenhauer, Elizabeth A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society of Clinical Oncology 2011
Fag:
Original Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158598/
https://ncbi.nlm.nih.gov/pubmed/21788564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.34.1578
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