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Human exonuclease 1 connects nucleotide excision repair (NER) processing with checkpoint activation in response to UV irradiation

UV light induces DNA lesions, which are removed by nucleotide excision repair (NER). Exonuclease 1 (EXO1) is highly conserved from yeast to human and is implicated in numerous DNA metabolic pathways, including repair, recombination, replication, and telomere maintenance. Here we show that hEXO1 is i...

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Detalhes bibliográficos
Main Authors: Sertic, Sarah, Pizzi, Sara, Cloney, Ross, Lehmann, Alan R., Marini, Federica, Plevani, Paolo, Muzi-Falconi, Marco
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3158162/
https://ncbi.nlm.nih.gov/pubmed/21808022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108547108
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