Standardization of Estrogen Receptor Measurement in Breast Cancer Suggests False-Negative Results Are a Function of Threshold Intensity Rather Than Percentage of Positive Cells

PURPOSE: Recent misclassification (false negative) incidents have raised awareness concerning limitations of immunohistochemistry (IHC) in assessment of estrogen receptor (ER) in breast cancer. Here we define a new method for standardization of ER measurement and then examine both change in percenta...

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Detalhes bibliográficos
Principais autores: Welsh, Allison W., Moeder, Christopher B., Kumar, Sudha, Gershkovich, Peter, Alarid, Elaine T., Harigopal, Malini, Haffty, Bruce G., Rimm, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2011
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157961/
https://ncbi.nlm.nih.gov/pubmed/21709197
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.32.9706
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