Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice

Pituitary adenylate cyclase-activating polypeptide (PACAP) has neuroprotective and neurotrophic properties and is a potent α-secretase activator. As PACAP peptides and their specific receptor PAC1 are localized in central nervous system areas affected by Alzheimer's disease (AD), this study aim...

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Autors principals: Rat, Dorothea, Schmitt, Ulrich, Tippmann, Frank, Dewachter, Ilse, Theunis, Clara, Wieczerzak, Ewa, Postina, Rolf, van Leuven, Fred, Fahrenholz, Falk, Kojro, Elzbieta
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2011
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157688/
https://ncbi.nlm.nih.gov/pubmed/21593432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.10-180133
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