A Locked Nucleic Acid Clamp-Mediated PCR Assay for Detection of a p53 Codon 249 Hotspot Mutation in Urine

Hepatocellular carcinoma (HCC) has a 5-year survival rate of <10% because it is difficult to diagnose early. Mutations in the TP53 gene are associated with approximately 50% of human cancers. A hotspot mutation, a G:C to T:A transversion at codon 249 (249T), may be a potential DNA marker for HCC...

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Enregistré dans:
Détails bibliographiques
Auteurs principaux: Lin, Selena Y., Dhillon, Veerpal, Jain, Surbhi, Chang, Ting-Tsung, Hu, Chi-Tan, Lin, Yih-Jyh, Chen, Shun-Hua, Chang, Kung-Chao, Song, Wei, Yu, Lixin, Block, Timothy M., Su, Ying-Hsiu
Format: Artigo
Langue:Inglês
Publié: American Society for Investigative Pathology 2011
Sujets:
Technical Advance
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157622/
https://ncbi.nlm.nih.gov/pubmed/21726666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmoldx.2011.05.005
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