Implicating Calpain in Tau-Mediated Toxicity In Vivo

Alzheimer's disease and other related neurodegenerative disorders known as tauopathies are characterized by the accumulation of abnormally phosphorylated and aggregated forms of the microtubule-associated protein tau. Several laboratories have identified a 17 kD proteolytic fragment of tau in d...

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Autori principali: Reinecke, James B., DeVos, Sarah L., McGrath, James P., Shepard, Amanda M., Goncharoff, Dustin K., Tait, Don N., Fleming, Samantha R., Vincent, Michael P., Steinhilb, Michelle L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2011
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157467/
https://ncbi.nlm.nih.gov/pubmed/21858230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023865
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