A Role for Vascular Deficiency in Retinal Pathology in a Mouse Model of Ataxia-Telangiectasia

Ataxia-telangiectasia is a multifaceted syndrome caused by null mutations in the ATM gene, which encodes the protein kinase ATM, a key participant in the DNA damage response. Retinal neurons are highly susceptible to DNA damage because they are terminally differentiated and have the highest metaboli...

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Detalhes bibliográficos
Main Authors: Raz-Prag, Dorit, Galron, Ronit, Segev-Amzaleg, Niva, Solomon, Arieh S., Shiloh, Yosef, Barzilai, Ari, Frenkel, Dan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Investigative Pathology 2011
Assuntos:
Regular Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3157193/
https://ncbi.nlm.nih.gov/pubmed/21763675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2011.05.026
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