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Role of phosphoinositide 3-kinase – Akt signaling pathway in the age-related cytokine dysregulation in splenic macrophages stimulated via TLR2 or TLR 4 receptors
Age-associated defects in both B-lymphocytes and macrophages in elderly result in a reduction in the efficacy of vaccines to many Gram positive bacteria like Streptococcus pneumoniae. Splenic macrophages from aged mice have been shown to have a defect in production of pro-inflammatory cytokines (IL-...
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| Hauptverfasser: | , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2011
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3155631/ https://ncbi.nlm.nih.gov/pubmed/21645538 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mad.2011.05.003 |
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