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Using a genetically targeted sensor to investigate the role of presenilin-1 in ER Ca(2+) levels and dynamics
The ER plays a fundamental role in storing cellular Ca(2+), generating Ca(2+) signals, and modulating Ca(2+) in both the cytosol and mitochondria. Genetically encoded Ca(2+) sensors can be explicitly targeted to the ER to directly define Ca(2+) levels and monitor fluxes of Ca(2+) within this organel...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2010
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3155245/ https://ncbi.nlm.nih.gov/pubmed/20379593 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c001975e |
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