The Acute Coagulopathy of Trauma is due to Impaired Initial Thrombin Generation but not Clot Formation or Clot Strength

The Acute Coagulopathy of Trauma (ACOT) has been described as a very early hypocoagulable state, but the mechanism remains controversial. One proposed mechanism is tissue hypoperfusion leading to protein C activation, with subsequent inhibition of Factors V and VIII. Variability in trauma has impede...

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Hauptverfasser: Harr, Jeffrey N., Moore, Ernest E., Wohlauer, Max V., Droz, Nathan, Fragoso, Miguel, Banerjee, Anirban, Silliman, Christopher C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154997/
https://ncbi.nlm.nih.gov/pubmed/21550061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jss.2011.03.047
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