Ascorbic acid in Charcot–Marie–Tooth disease type 1A (CMT-TRIAAL and CMT-TRAUK): a double-blind randomised trial

BACKGROUND: Ascorbic acid reduced the severity of neuropathy in transgenic mice overexpressing peripheral myelin protein 22 (PMP22), a model of Charcot–Marie–Tooth disease type 1A (CMT1A) associated with the PMP22 duplication. However, in three 1-year trials, ascorbic acid had no benefit in human be...

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Main Authors: Pareyson, Davide, Reilly, Mary M, Schenone, Angelo, Fabrizi, Gian Maria, Cavallaro, Tiziana, Santoro, Lucio, Vita, Giuseppe, Quattrone, Aldo, Padua, Luca, Gemignani, Franco, Visioli, Francesco, Laurà, Matilde, Radice, Davide, Calabrese, Daniela, Hughes, Richard AC, Solari, Alessandra
Format: Artigo
Language:Inglês
Published: Lancet Pub. Group 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154498/
https://ncbi.nlm.nih.gov/pubmed/21393063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/S1474-4422(11)70025-4
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