Hepatic n-3 Polyunsaturated Fatty Acid Depletion Promotes Steatosis and Insulin Resistance in Mice: Genomic Analysis of Cellular Targets

Patients with non-alcoholic fatty liver disease are characterised by a decreased n-3/n-6 polyunsaturated fatty acid (PUFA) ratio in hepatic phospholipids. The metabolic consequences of n-3 PUFA depletion in the liver are poorly understood. We have reproduced a drastic drop in n-3 PUFA among hepatic...

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Main Authors: Pachikian, Barbara D., Essaghir, Ahmed, Demoulin, Jean-Baptiste, Neyrinck, Audrey M., Catry, Emilie, De Backer, Fabienne C., Dejeans, Nicolas, Dewulf, Evelyne M., Sohet, Florence M., Portois, Laurence, Deldicque, Louise, Molendi-Coste, Olivier, Leclercq, Isabelle A., Francaux, Marc, Carpentier, Yvon A., Foufelle, Fabienne, Muccioli, Giulio G., Cani, Patrice D., Delzenne, Nathalie M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3154437/
https://ncbi.nlm.nih.gov/pubmed/21853118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023365
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