Oxidative stress through activation of NAD(P)H oxidase in hypertensive mice with spontaneous intracranial hemorrhage

We have developed an experimental model of spontaneous intracranial hemorrhage (ICH) in transgenic mice expressing human renin and human angiotensinogen (R + /A +) treated with high-salt diet and N(ω)-nitro-l-arginine methyl ester (l-NAME). We investigated whether oxidative stress is associated with...

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Autori principali: Wakisaka, Yoshinobu, Miller, Jordan D, Chu, Yi, Baumbach, Gary L, Wilson, Saul, Faraci, Frank M, Sigmund, Curt D, Heistad, Donald D
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3153951/
https://ncbi.nlm.nih.gov/pubmed/18301433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/jcbfm.2008.7
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