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Rapid pacing of embryoid bodies impairs mitochondrial ATP synthesis by a calcium-dependent mechanism—A model of in vitro differentiated cardiomyocytes to study molecular effects of tachycardia

Tachycardia may cause substantial molecular and ultrastructural alterations in cardiac tissue. The underlying pathophysiology has not been fully explored. The purpose of this study was (I) to validate a three-dimensional in vitro pacing model, (II) to examine the effect of rapid pacing on mitochondr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Schild, Lorenz, Bukowska, Alicja, Gardemann, Andreas, Polczyk, Pamela, Keilhoff, Gerburg, Täger, Michael, Dudley, Samuel C., Klein, Helmut U., Goette, Andreas, Lendeckel, Uwe
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2006
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3153943/
https://ncbi.nlm.nih.gov/pubmed/16644187
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2006.03.005
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