Dietary Cholesterol Reduces Plasma Triacylglycerol in Apolipoprotein E-Null Mice: Suppression of Lipin-1 and -2 in the Glycerol-3-Phosphate Pathway

BACKGROUND: Cholesterol metabolism is tightly regulated by both cholesterol and its metabolites in the mammalian liver, but the regulatory mechanism of triacylglycerol (TG) synthesis remains to be elucidated. Lipin, which catalyzes the conversion of phosphatidate to diacylglycerol, is a key enzyme i...

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Detalhes bibliográficos
Main Authors: Obama, Takashi, Nagaoka, Sayaka, Akagi, Kazuki, Kato, Rina, Horiuchi, Naomi, Horai, Yasushi, Aiuchi, Toshihiro, Arata, Satoru, Yamaguchi, Tomohiro, Watanabe, Mitsuhiro, Itabe, Hiroyuki
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3153461/
https://ncbi.nlm.nih.gov/pubmed/21857965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022917
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