Single Nucleotide Polymorphisms that Increase Expression of the GTPase RAC1 are Associated with Ulcerative Colitis

BACKGROUND & AIMS: RAC1 is a GTPase that has an evolutionarily conserved role in coordinating immune defenses, from plants to mammals. Chronic inflammatory bowel diseases (IBD) are associated with dysregulation of immune defenses. We studied the role of RAC1 in IBD using human genetic and functi...

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Main Authors: Muise, Aleixo M, Walters, Thomas, Xu, Wei, Shen-Tu, Grace, Guo, Cong-Hui, Fattouh, Ramzi, Lam, Grace Y, Wolters, Victorien M, Bennitz, Joshua, Van Limbergen, Johan, Renbaum, Paul, Kasirer, Yair, Ngan, Bo-Yee, Turner, Dan, Denson, Lee A, Sherman, Philip M, Duerr, Richard H, Cho, Judy, Lees, Charlie W, Satsangi, Jack, Wilson, David C, Paterson, Andrew D, Griffiths, Anne M, Glogauer, Michael, Silverberg, Mark S, Brumell, John H
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3152589/
https://ncbi.nlm.nih.gov/pubmed/21684284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2011.04.057
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