Gcn4 misregulation reveals a direct role for the evolutionary conserved EKC/KEOPS in the t(6)A modification of tRNAs

The EKC/KEOPS complex is universally conserved in Archaea and Eukarya and has been implicated in several cellular processes, including transcription, telomere homeostasis and genomic instability. However, the molecular function of the complex has remained elusive so far. We analyzed the transcriptom...

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Detalhes bibliográficos
Main Authors: Daugeron, Marie-Claire, Lenstra, Tineke L., Frizzarin, Martina, El Yacoubi, Basma, Liu, Xipeng, Baudin-Baillieu, Agnès, Lijnzaad, Philip, Decourty, Laurence, Saveanu, Cosmin, Jacquier, Alain, Holstege, Frank C. P., de Crécy-Lagard, Valérie, van Tilbeurgh, Herman, Libri, Domenico
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
Assuntos:
RNA
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3152333/
https://ncbi.nlm.nih.gov/pubmed/21459853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkr178
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