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Immunoglobulin Light Chains Activate Tubular Epithelial Cells through Redox Signaling
The renal proximal tubule metabolizes circulating low-molecular-weight proteins such as Ig free light chains. In the setting of plasma cell dyscrasias, the burden of filtered protein can be very high. Endocytosis of certain nephrotoxic light chains induces H(2)O(2) production and monocyte chemoattra...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Nephrology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3152234/ https://ncbi.nlm.nih.gov/pubmed/20558542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2009101089 |
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