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Identification of Cryptic Products of the Gliotoxin Gene Cluster using NMR-based Comparative Metabolomics and a Model for Gliotoxin Biosynthesis
Gliotoxin (1), a major product of the gli non-ribosomal peptide synthetase (NRPS) gene cluster, is strongly associated with virulence of the opportunistic human pathogen Aspergillus fumigatus. Despite identification of the gli cluster, the pathway of gliotoxin biosynthesis has remained elusive, in p...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3151163/ https://ncbi.nlm.nih.gov/pubmed/21612254 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja2029987 |
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