Unique carbohydrate–carbohydrate interactions are required for high affinity binding between FcγRIII and antibodies lacking core fucose

Antibody-mediated cellular cytotoxicity (ADCC), a key immune effector mechanism, relies on the binding of antigen–antibody complexes to Fcγ receptors expressed on immune cells. Antibodies lacking core fucosylation show a large increase in affinity for FcγRIIIa leading to an improved receptor-mediate...

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Bibliographische Detailangaben
Hauptverfasser: Ferrara, Claudia, Grau, Sandra, Jäger, Christiane, Sondermann, Peter, Brünker, Peter, Waldhauer, Inja, Hennig, Michael, Ruf, Armin, Rufer, Arne Christian, Stihle, Martine, Umaña, Pablo, Benz, Jörg
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2011
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150898/
https://ncbi.nlm.nih.gov/pubmed/21768335
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1108455108
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