The Global DNA Methylation Surrogate LINE-1 Methylation Is Correlated with MGMT Promoter Methylation and Is a Better Prognostic Factor for Glioma

Gliomas are the most frequently occurring primary brain tumor in the central nervous system of adults. Glioblastoma multiformes (GBMs, WHO grade 4) have a dismal prognosis despite the use of the alkylating agent, temozolomide (TMZ), and even low grade gliomas (LGGs, WHO grade 2) eventually transform...

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Detalhes bibliográficos
Main Authors: Ohka, Fumiharu, Natsume, Atsushi, Motomura, Kazuya, Kishida, Yugo, Kondo, Yutaka, Abe, Tatsuya, Nakasu, Yoko, Namba, Hiroki, Wakai, Kenji, Fukui, Takashi, Momota, Hiroyuki, Iwami, Kenichiro, Kinjo, Sayano, Ito, Maki, Fujii, Masazumi, Wakabayashi, Toshihiko
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150434/
https://ncbi.nlm.nih.gov/pubmed/21829728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023332
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