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NF-κB signaling participates in both Receptor Activator of NF-κB Ligand- (RANKL) and interleukin-4- (IL-4) induced macrophage fusion: Receptor cross-talk leads to alterations in NF-κB pathways

NF-κB activation is essential for RANKL-induced osteoclast formation. IL-4 is known to inhibit the RANKL-induced osteoclast differentiation, while at the same time promote macrophage fusion to form multinucleated giant cells (MNG). Several groups have proposed that IL-4 inhibition of osteoclastogene...

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Autors principals: Yu, Minjun, Qi, Xiulan, Moreno, Jose L., Farber, Donna L., Keegan, Achsah D.
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150418/
https://ncbi.nlm.nih.gov/pubmed/21734075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1002628
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