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Exposure of Neurons to Excitotoxic Levels of Glutamate Induces Cleavage of ADAR2 and Loss of GluR2 Editing

AMPA receptors are glutamate receptors that are tetramers of various combinations of GluR1-4 subunits. AMPA receptors containing GluR1, 3 and 4 are Ca(2+) permeable, however, AMPA receptors containing even a single subunit of GluR2 are Ca(2+) impermeable. Most AMPA receptors are Ca(2+) impermeable d...

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Autors principals: Mahajan, Shahana S, Thai, Khanh H., Chen, Karen, Ziff, Edward
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150305/
https://ncbi.nlm.nih.gov/pubmed/21620933
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2011.05.027
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