Uveitis-associated epitopes of retinal antigens are pathogenic in the humanized mouse model of uveitis and identify autoaggressive T cells

Noninfectious uveitis is a leading cause of blindness and is thought to involve autoimmune T cell responses to retinal proteins, e.g., retinal arrestin (S-Ag). There are no known biomarkers for the disease. Susceptibility is associated with HLA, but little is known about susceptible class II alleles...

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Main Authors: Mattapallil, Mary J., Silver, Phyllis B., Mattapallil, Joseph J., Horai, Reiko, Karabekian, Zaruhi, McDowell, J. Hugh, Chan, Chi-Chao, James, Eddie A., Kwok, William W., Sen, H. Nida, Nussenblatt, Robert B., David, Chella S., Caspi, Rachel R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3150271/
https://ncbi.nlm.nih.gov/pubmed/21765017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1101247
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