Loss of Thr286 phosphorylation disrupts synaptic CaMKIIα targeting, NMDAR activity and behavior in pre-adolescent mice

In order to provide insight into in vivo roles of CaMKIIα autophosphorylation at Thr286 during postnatal development, behavioral, biochemical, and electrophysiological phenotypes of pre-adolescent Thr286 to Ala CaMKIIα knock-in (T286A-KI) and WT mice were examined. T286A-KI mice displayed cognitive...

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Main Authors: Gustin, Richard M., Shonesy, Brian C., Robinson, Stacey L., Rentz, Tyler J., Baucum, Anthony J., Jalan-Sakrikar, Nidhi, Winder, Danny G., Stanwood, Gregg D., Colbran, Roger J.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149813/
https://ncbi.nlm.nih.gov/pubmed/21627991
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2011.05.006
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