Is CFTR-delF508 Really Absent from the Apical Membrane of the Airway Epithelium?

BACKGROUND: Understanding where mutant CFTR is localised in airway epithelia is essential in guiding the best therapeutic approach to correct the dysfunction of the CFTR protein. The widely held paradigm is that CF patients harbouring the commonest mutation, CFTR-delF508, trap CFTR within the endopl...

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Autors principals: Borthwick, Lee A., Botha, Phil, Verdon, Bernard, Brodlie, Malcolm J., Gardner, Aaron, Bourn, David, Johnson, Gail E., Gray, Mike A., Fisher, Andrew J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2011
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149652/
https://ncbi.nlm.nih.gov/pubmed/21826241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0023226
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