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2-Aminophenoxazine-3-one and 2-amino-4,4α-dihydro-4α,7-dimethyl-3H-phenoxazine-3-one cause cellular apoptosis by reducing higher intracellular pH in cancer cells

We examined intracellular pH (pHi) of ten cancer cell lines derived from different organs and two normal cell lines including human embryonic lung fibroblast cells (HEL) and human umbilical vein endothelial cells (HUVEC) in vitro, and found that pHi of most of these cancer cells was evidently higher...

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Detalhes bibliográficos
Main Authors: CHE, Xiao-Fang, ZHENG, Chun-Lei, AKIYAMA, Shin-Ichi, TOMODA, Akio
Formato: Artigo
Idioma:Inglês
Publicado em: The Japan Academy 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149379/
https://ncbi.nlm.nih.gov/pubmed/21558757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2183/pjab.87.199
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