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Shortened Engineered Human Antibody CH2 Domains: INCREASED STABILITY AND BINDING TO THE HUMAN NEONATAL Fc RECEPTOR
The immunoglobulin (Ig) constant CH2 domain is critical for antibody effector functions. Isolated CH2 domains are promising scaffolds for construction of libraries containing diverse binders that could also confer some effector functions. We have shown previously that an isolated human CH2 domain is...
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| Auteurs principaux: | , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Biochemistry and Molecular Biology
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3149322/ https://ncbi.nlm.nih.gov/pubmed/21669873 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.254219 |
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