Shortened Engineered Human Antibody CH2 Domains: INCREASED STABILITY AND BINDING TO THE HUMAN NEONATAL Fc RECEPTOR

The immunoglobulin (Ig) constant CH2 domain is critical for antibody effector functions. Isolated CH2 domains are promising scaffolds for construction of libraries containing diverse binders that could also confer some effector functions. We have shown previously that an isolated human CH2 domain is...

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Detalles Bibliográficos
Autores principales: Gong, Rui, Wang, Yanping, Feng, Yang, Zhao, Qi, Dimitrov, Dimiter S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Materias:
Protein Structure and Folding
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149322/
https://ncbi.nlm.nih.gov/pubmed/21669873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.254219
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