Shortened Engineered Human Antibody CH2 Domains: INCREASED STABILITY AND BINDING TO THE HUMAN NEONATAL Fc RECEPTOR

The immunoglobulin (Ig) constant CH2 domain is critical for antibody effector functions. Isolated CH2 domains are promising scaffolds for construction of libraries containing diverse binders that could also confer some effector functions. We have shown previously that an isolated human CH2 domain is...

Full description

Saved in:
Bibliographic Details
Main Authors: Gong, Rui, Wang, Yanping, Feng, Yang, Zhao, Qi, Dimitrov, Dimiter S.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2011
Subjects:
Protein Structure and Folding
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149322/
https://ncbi.nlm.nih.gov/pubmed/21669873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.254219
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items