Modulation of Pancreatic Cancer Chemoresistance by Inhibition of TAK1

BACKGROUND: TGF-β-activated kinase-1 (TAK1), a mitogen-activated protein kinase kinase kinase, functions in the activation of nuclear factor κB (NF-κB) and activator protein-1, which can suppress proapoptotic signaling pathways and thus promote resistance to chemotherapeutic drugs. However, it is no...

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Main Authors: Melisi, Davide, Xia, Qianghua, Paradiso, Genni, Ling, Jianhua, Moccia, Tania, Carbone, Carmine, Budillon, Alfredo, Abbruzzese, James L., Chiao, Paul J.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3149044/
https://ncbi.nlm.nih.gov/pubmed/21743023
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jnci/djr243
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