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Leukemia-free survival as a surrogate end point for overall survival in the evaluation of maintenance therapy for patients with acute myeloid leukemia in complete remission

BACKGROUND: In trials designed to evaluate new therapies for hematologic malignancies, end points such as leukemia-free survival are often used as surrogates for overall survival in acute leukemia. We aimed to assess whether leukemia-free survival is an acceptable statistical surrogate for overall s...

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Detalhes bibliográficos
Main Authors: Buyse, Marc, Michiels, Stefan, Squifflet, Pierre, Lucchesi, Kathryn J., Hellstrand, Kristoffer, Brune, Mats L., Castaigne, Sylvie, Rowe, Jacob M.
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148903/
https://ncbi.nlm.nih.gov/pubmed/21546500
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2010.039131
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