IHG-1 Promotes Mitochondrial Biogenesis by Stabilizing PGC-1α

Increased expression of Induced-by-High-Glucose 1 (IHG-1) associates with tubulointerstitial fibrosis in diabetic nephropathy. IHG-1 amplifies TGF-β1 signaling, but the functions of this highly-conserved protein are not well understood. IHG-1 contains a putative mitochondrial-localization domain, an...

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Главные авторы: Hickey, Fionnuala B., Corcoran, James B., Docherty, Neil G., Griffin, Brenda, Bhreathnach, Una, Furlong, Fiona, Martin, Finian, Godson, Catherine, Murphy, Madeline
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Nephrology 2011
Предметы:
Basic Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148702/
https://ncbi.nlm.nih.gov/pubmed/21784897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2010111154
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