A Prokaryotic S1P Lyase Degrades Extracellular S1P In Vitro and In Vivo: Implication for Treating Hyperproliferative Disorders

Sphingosine-1-phosphate (S1P) regulates a broad spectrum of fundamental cellular processes like proliferation, death, migration and cytokine production. Therefore, elevated levels of S1P may be causal to various pathologic conditions including cancer, fibrosis, inflammation, autoimmune diseases and...

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Detalhes bibliográficos
Main Authors: Huwiler, Andrea, Bourquin, Florence, Kotelevets, Nataliya, Pastukhov, Oleksandr, Capitani, Guido, Grütter, Markus G., Zangemeister-Wittke, Uwe
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3148216/
https://ncbi.nlm.nih.gov/pubmed/21829623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022436
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