Detection of Minority Resistance during Early HIV-1 Infection: Natural Variation and Spurious Detection rather than Transmission and Evolution of Multiple Viral Variants

Reports of a high frequency of the transmission of minority viral populations with drug-resistant mutations (DRM) are inconsistent with evidence that HIV-1 infections usually arise from mono- or oligoclonal transmission. We performed ultradeep sequencing (UDS) of partial HIV-1 gag, pol, and env gene...

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Detalhes bibliográficos
Main Authors: Gianella, Sara, Delport, Wayne, Pacold, Mary E., Young, Jason A., Choi, Jun Yong, Little, Susan J., Richman, Douglas D., Kosakovsky Pond, Sergei L., Smith, Davey M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Genetic Diversity and Evolution
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147985/
https://ncbi.nlm.nih.gov/pubmed/21632754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02582-10
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