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Sterol Regulatory Element-Binding Protein 2 Couples HIV-1 Transcription to Cholesterol Homeostasis and T Cell Activation

Cholesterol plays an essential role in the life cycle of several enveloped viruses. Many of these viruses manipulate host cholesterol metabolism to facilitate their replication. HIV-1 infection of CD4(+) T cells activates the sterol regulatory element-binding protein 2 (SREBP2) transcriptional progr...

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Autors principals: Taylor, Harry E., Linde, Michael E., Khatua, Atanu K., Popik, Waldemar, Hildreth, James E. K.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2011
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147916/
https://ncbi.nlm.nih.gov/pubmed/21613400
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00337-11
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