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A simple model based on mutation and selection explains trends in codon and amino-acid usage and GC composition within and across genomes

BACKGROUND: Correlations between genome composition (in terms of GC content) and usage of particular codons and amino acids have been widely reported, but poorly explained. We show here that a simple model of processes acting at the nucleotide level explains codon usage across a large sample of spec...

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Autori principali: Knight, Robin D, Freeland, Stephen J, Landweber, Laura F
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2001
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC31479/
https://ncbi.nlm.nih.gov/pubmed/11305938
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