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Hypoxia-Induced Epigenetic Regulation and Silencing of the BRCA1 Promoter
Disruption of the BRCA1 tumor suppressor can be caused not only by inherited mutations in familial cancers but also by BRCA1 gene silencing in sporadic cancers. Hypoxia, a key feature of the tumor microenvironment, has been shown to downregulate BRCA1 at the transcriptional level via repressive E2F4...
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| Auteurs principaux: | , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2011
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3147797/ https://ncbi.nlm.nih.gov/pubmed/21670155 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01121-10 |
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