Importance of a Hydrophobic Pocket for Peptide Binding in Lactococcal OppA

Lactococcal oligopeptide-binding protein A (OppA) binds peptides with widely varied lengths and sequences. We previously hypothesized that a hydrophobic pocket in OppA preferentially binds a hydrophobic peptide side chain and thus determines its binding register. Two crystal structures of OppA with...

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Hauptverfasser: Berntsson, Ronnie P.-A., Thunnissen, Andy-Mark W. H., Poolman, Bert, Slotboom, Dirk-Jan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2011
Schlagworte:
Enzymes and Proteins
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147668/
https://ncbi.nlm.nih.gov/pubmed/21665971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00447-11
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