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Low Fitness Cost of the Multidrug Resistance Gene cfr

The recently described rRNA methyltransferase Cfr that methylates the conserved 23S rRNA residue A2503, located in a functionally critical region of the ribosome, confers resistance to an array of ribosomal antibiotics, including linezolid. A number of reports of linezolid-resistant cfr-positive cli...

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Bibliografiske detaljer
Main Authors: LaMarre, Jacqueline M., Locke, Jeffrey B., Shaw, Karen J., Mankin, Alexander S.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147626/
https://ncbi.nlm.nih.gov/pubmed/21646483
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00153-11
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