Crystal structure of the N-terminal region of human Ash2L shows a winged-helix motif involved in DNA binding

Ash2L is a core component of the MLL family histone methyltransferases and has an important role in regulating the methylation of histone H3 on lysine 4. Here, we report the crystal structure of the N-terminal domain of Ash2L and reveal a new function of Ash2L. The structure shows that Ash2L contain...

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Detalhes bibliográficos
Main Authors: Chen, Yong, Wan, Bingbing, Wang, Kevin C, Cao, Fang, Yang, Yuting, Protacio, Angeline, Dou, Yali, Chang, Howard Y, Lei, Ming
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Scientific Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147254/
https://ncbi.nlm.nih.gov/pubmed/21660059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/embor.2011.101
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