Meta-analysis of genome-wide association studies in >80,000 subjects identifies multiple loci for C-reactive protein levels

BACKGROUND: C-reactive protein (CRP) is a heritable marker of chronic inflammation that is strongly associated with cardiovascular disease. We aimed to identify genetic variants that are associated with CRP levels. METHODS AND RESULTS: We performed a genome wide association (GWA) analysis of CRP in...

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Hauptverfasser: Dehghan, Abbas, Dupuis, Josée, Barbalic, Maja, Bis, Joshua C, Eiriksdottir, Gudny, Lu, Chen, Pellikka, Niina, Wallaschofski, Henri, Kettunen, Johannes, Henneman, Peter, Baumert, Jens, Strachan, David P, Fuchsberger, Christian, Vitart, Veronique, Wilson, James F, Paré, Guillaume, Naitza, Silvia, Rudock, Megan E, Surakka, Ida, de Geus, Eco JC, Alizadeh, Behrooz Z, Guralnik, Jack, Shuldiner, Alan, Tanaka, Toshiko, Zee, Robert YL, Schnabel, Renate B, Nambi, Vijay, Kavousi, Maryam, Ripatti, Samuli, Nauck, Matthias, Smith, Nicholas L, Smith, Albert V, Sundvall, Jouko, Scheet, Paul, Liu, Yongmei, Ruokonen, Aimo, Rose, Lynda M, Larson, Martin G, Hoogeveen, Ron C, Freimer, Nelson B, Teumer, Alexander, Tracy, Russell P, Launer, Lenore J, Buring, Julie E, Yamamoto, Jennifer F, Folsom, Aaron R, Sijbrands, Eric JG, Pankow, James, Elliott, Paul, Keaney, John F, Sun, Wei, Sarin, Antti-Pekka, Fontes, João D, Badola, Sunita, Astor, Brad C, Hofman, Albert, Pouta, Anneli, Werdan, Karl, Greiser, Karin H, Kuss, Oliver, Meyer zu Schwabedissen, Henriette E, Thiery, Joachim, Jamshidi, Yalda, Nolte, Ilja M, Soranzo, Nicole, Spector, Timothy D, Völzke, Henry, Parker, Alexander N, Aspelund, Thor, Bates, David, Young, Lauren, Tsui, Kim, Siscovick, David S, Guo, Xiuqing, Rotter, Jerome I, Uda, Manuela, Schlessinger, David, Rudan, Igor, Hicks, Andrew A, Penninx, Brenda W, Thorand, Barbara, Gieger, Christian, Coresh, Joe, Willemsen, Gonneke, Harris, Tamara B, Uitterlinden, Andre G, Järvelin, Marjo-Riitta, Rice, Kenneth, Radke, Dörte, Salomaa, Veikko, van Dijk, Ko Willems, Boerwinkle, Eric, Vasan, Ramachandran S, Ferrucci, Luigi, Gibson, Quince D, Bandinelli, Stefania, Snieder, Harold, Boomsma, Dorret I, Xiao, Xiangjun, Campbell, Harry, Hayward, Caroline, Pramstaller, Peter P, van Duijn, Cornelia M, Peltonen, Leena, Psaty, Bruce M, Gudnason, Vilmundur, Ridker, Paul M, Homuth, Georg, Koenig, Wolfgang, Ballantyne, Christie M, Witteman, Jacqueline CM, Benjamin, Emelia J, Perola, Markus, Chasman, Daniel I
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3147232/
https://ncbi.nlm.nih.gov/pubmed/21300955
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.110.948570
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