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Interleukin-2 rescues helpless effector CD8(+) T cells by diminishing the susceptibility to TRAIL mediated death

CD8(+) T cells primed in the absence of CD4(+) T cell help are programmed to produce TRAIL, which results in Death receptor (DR5) mediated apoptosis upon restimulation. Here, we studied whether these `helpless' effector CD8(+) T cells are consigned to an apoptotic fate or whether their helpless...

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Bibliografiske detaljer
Main Authors: Wolkers, Monika C., Bensinger, Steven J., Green, Douglas R., Schoenberger, Stephen P., Janssen, Edith M.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3146632/
https://ncbi.nlm.nih.gov/pubmed/21621553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.imlet.2011.04.011
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