Pancreatic β-Cell Death in Response to Pro-Inflammatory Cytokines Is Distinct from Genuine Apoptosis

A reduction in functional β-cell mass leads to both major forms of diabetes; pro-inflammatory cytokines, such as interleukin-1beta (IL-1β) and gamma-interferon (γ-IFN), activate signaling pathways that direct pancreatic β-cell death and dysfunction. However, the molecular mechanism of β-cell death i...

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Bibliographic Details
Main Authors: Collier, J. Jason, Burke, Susan J., Eisenhauer, Mary E., Lu, Danhong, Sapp, Renee C., Frydman, Carlie J., Campagna, Shawn R.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3146470/
https://ncbi.nlm.nih.gov/pubmed/21829464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0022485
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