INGN-225: a dendritic cell-based p53 vaccine (Ad.p53-DC) in small cell lung cancer: observed association between immune response and enhanced chemotherapy effect

IMPORTANCE OF THE FIELD: Novel approaches are needed for patients with small cell lung cancer (SCLC), as response after relapse is poor with standard therapies. p53 gene mutations often occur, resulting in tumoral protein overexpression and allowing for their recognition by p53-specific cytotoxic T...

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Autores principales: Chiappori, Alberto A, Soliman, Hatem, Janssen, William E, Antonia, Scott J, Gabrilovich, Dmitry I
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3146364/
https://ncbi.nlm.nih.gov/pubmed/20420527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/14712598.2010.484801
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