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Histone deacetylase inhibitors induce TAP, LMP, Tapasin genes and MHC class I antigen presentation by melanoma cells

Histone deacetylase inhibitors (HDACi), including trichostatin A (TSA) and valproic acid, can alter the acetylation of histones in chromatin and enhance gene transcription. Previously we demonstrated that HDACi-treated tumor cells are capable of presenting antigen via the MHC class II pathway. In th...

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Bibliographische Detailangaben
Hauptverfasser: Khan, A. Nazmul H., Gregorie, Christopher J., Tomasi, Thomas B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2007
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3146348/
https://ncbi.nlm.nih.gov/pubmed/18046553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-007-0402-4
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