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A Robust Method for comparing Two Treatments in a Confirmatory Clinical Trial via Multivariate Time-to-event Methods that jointly incorporate Information from Longitudinal and Time-to-event Data

We consider regulatory clinical trials that required a pre-specified method for the comparison of two treatments for chronic diseases (e.g. Chronic Obstructive Pulmonary Disease) in which patients suffer deterioration in a longitudinal process until death occurs. We define a composite endpoint struc...

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Autors principals: Saville, Benjamin R., Herring, Amy H., Koch, Gary G.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3146347/
https://ncbi.nlm.nih.gov/pubmed/19830704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/sim.3740
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