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Pervasive Sign Epistasis between Conjugative Plasmids and Drug-Resistance Chromosomal Mutations

Multidrug-resistant bacteria arise mostly by the accumulation of plasmids and chromosomal mutations. Typically, these resistant determinants are costly to the bacterial cell. Yet, recently, it has been found that, in Escherichia coli bacterial cells, a mutation conferring resistance to an antibiotic...

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Библиографические подробности
Главные авторы: Silva, Rui F., Mendonça, Sílvia C. M., Carvalho, Luís M., Reis, Ana M., Gordo, Isabel, Trindade, Sandra, Dionisio, Francisco
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2011
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145620/
https://ncbi.nlm.nih.gov/pubmed/21829372
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002181
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