p16(INK4A) and p14(ARF) Tumor Suppressor Pathways Are Deregulated in Malignant Rhabdoid Tumors

Malignant rhabdoid tumors (MRT) are aggressive tumors associated with mutations in the SMARCB1 gene. In experimental systems, the loss of SMARCB1 is hypothesized to alter p16(INK4A) pathways resulting in repression of tumor suppressors. To determine whether these pathways are deregulated in human MR...

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Main Authors: Venneti, Sriram, Le, Paul, Martinez, Daniel, Eaton, Katherine W., Shyam, Nikhil, Jordan-Sciutto, Kelly L., Pawel, Bruce, Biegel, Jaclyn A., Judkins, Alexander R.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3145456/
https://ncbi.nlm.nih.gov/pubmed/21666498
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/NEN.0b013e31822146ca
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