Fenretinide metabolism in humans and mice: utilizing pharmacological modulation of its metabolic pathway to increase systemic exposure

BACKGROUND AND PURPOSE: High plasma levels of fenretinide [N-(4-hydroxyphenyl)retinamide (4-HPR)] were associated with improved outcome in a phase II clinical trial. Low bioavailability of 4-HPR has been limiting its therapeutic applications. This study characterized metabolism of 4-HPR in humans an...

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Autors principals: Cooper, Jason P, Hwang, Kyunghwa, Singh, Hardeep, Wang, Dong, Reynolds, C Patrick, Curley, Robert W, Williams, Simon C, Maurer, Barry J, Kang, Min H
Format: Artigo
Idioma:Inglês
Publicat: Blackwell Science Inc 2011
Matèries:
Research Papers
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3144539/
https://ncbi.nlm.nih.gov/pubmed/21391977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2011.01310.x
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